Pharmacognosy intro
Copal's PRIMARY active compounds are pentacyclic triterpenes, alpha-amyrin, beta-amyrin, alpha-amyrenone, beta-amyrenone, and lupeol. The volatile aromatic fraction contains monoterpenes (alpha-pinene, beta-pinene, limonene, sabinene, myrcene), sesquiterpenes (beta-caryophyllene, germacrene D, alpha-copaene), and diterpenes (labdane and clerodane types). Resin acids include communic acid and imbricataloic acid. Three commercial types differ: Copal Blanco (highest monoterpene content, freshest, lightest smoke), Copal Oro (balanced terpene profile, partially aged, richer aroma), and Copal Negro (highest triterpene content, most aged, deepest smoke). Alpha-amyrin and beta-amyrin inhibit the NF-kB pathway, reducing TNF-alpha, IL-1beta, and PGE2. Lupeol inhibits phospholipase A2 and COX-2. Beta-caryophyllene is a dietary cannabinoid that selectively binds CB2 receptor (anti-inflammatory, no psychoactive effect), one of the most pharmacologically interesting terpenes in copal smoke. Alpha-pinene and limonene modulate GABAergic transmission. Archaeological GC-MS analysis confirms copal residues in Mayan temple incensarios dating to 300-900 CE, demonstrating 1,700+ years of continuous use.