Pharmacognosy intro
Pelargonium graveolens L'Her. (Geraniaceae), commonly known as Rose Geranium, yields essential oil from aerial parts (leaves and stems) via steam distillation. Note that aromatherapy "geranium" is Pelargonium, a different genus from botanical Geranium used in Western herbalism. Over 32 compounds have been identified, with monoterpenes comprising 68.98% of the oil (Boukhris et al., 2013). Primary constituents include citronellol (25-45%), geraniol (5-18%), citronellyl formate (7-15%), linalool (4-8%), geranyl formate (2-6%), 10-epi-gamma-eudesmol (3-8%), and rose oxide. Geraniol suppresses COX-2 and NF-kB expression, reducing inflammatory processes closely associated with anxiety disorders and pain perception (Vieira et al., 2025). It also enhances superoxide dismutase activity for antioxidant neuroprotection. Citronellol binds to olfactory bulb receptors impacting the limbic system (emotional center), producing indirect anxiolytic effects through the olfactory-limbic pathway. Pelargonium oils relax smooth muscle through the adenylate cyclase/cAMP second messenger pathway. The overall anxiolytic effect is likely mediated through interaction with the hypothalamic-pituitary-adrenal axis (Lizarraga-Valderrama, 2020). A systematic review of 12 studies found that geranium essential oil demonstrated significant efficacy in improving PMS symptoms, dermatological and oral conditions, anxiety, and pain, with a favorable safety profile (Vieira, Barbosa, & Gnatta, 2025, Flavour and Fragrance Journal). In a triple-blind RCT (n=80), geranium inhalation via absorbing patches in oxygen masks over 2 days produced significant reduction in STAI anxiety scores in acute myocardial infarction patients (Shirzadegan et al., 2017). An RCT (n=100) in laboring women found that geranium on fabric attached to the collar significantly reduced both anxiety scores and diastolic blood pressure within 20 minutes (Rashidi Fakari et al., 2015). Geranium shares its dominant citronellol-geraniol chemistry with Rosa damascena but delivers it at significantly lower cost. Its role as a "harmonizer" in essential oil blending reflects its balanced pharmacological profile: anti-inflammatory, anxiolytic, and hormonally balancing without strong sedation or stimulation.